abstract：BACKGROUND:Bone grafting is commonly used to repair bone defects. As the porosity of the graft scaffold increases, bone formation increases, but the strength decreases. Early attempts to engineer materials were not able to resolve this problem. In recent years, nanomaterials have demonstrated the unique ability to impr...

journal_title：Chinese medical journal

authors： Tang D,Xu G,Yang Z,Holz J,Ye X,Cai S,Yuan W,Wang Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Orthotopic liver transplantation (OLT) has become the therapeutic option of choice for end-stage liver disease. The aim of this study was to investigate the changes of splenic morphology, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), apparent diffusion coefficient (ADC) values and explore their...

journal_title：Chinese medical journal

authors： Wang J,Liang Y,Yan R,Jiang Z,Liu J,Hu B,He B,Ren L,Chen J,Shan H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 (A2(-/-)A3(-/-)) displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone sho...

journal_title：Chinese medical journal

authors： Zhu R,Cho KS,Chen DF,Yang L

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To review the development of T follicular helper (TFH) cells and their role in systemic lupus erythematosus (SLE) pathogenesis, the effect of dendritic cells (DCs) on TFH cells in SLE, as well as the potential use of TFH cells as a new therapeutic target in clinical practice. DATA SOURCES:The data used in th...

journal_title：Chinese medical journal

authors： Ma H,Wan S,Xia C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) contribute to tumorigenesis by acting as either oncogenes or tumor suppressor genes. In this study, we investigated the role of miR-145 in the pathogenesis of uveal melanoma. METHODS:Expression profiles of miRNAs in uveal melanoma were performed using Agilent miRNA array. Quantitative rea...

journal_title：Chinese medical journal

authors： Li Y,Huang Q,Shi X,Jin X,Shen L,Xu X,Wei W

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Personalized medicine becomes essential in lung cancer treatment, however lung-cancer-related gene expression profiles in Chinese patients remain unknown. In this study, the correlation of gene expression profiles and clinical characteristics in non-small-cell lung cancer (NSCLC) was investigated. METHODS:S...

journal_title：Chinese medical journal

authors： Yu D,Li J,Han Y,Liu S,Xiao N,Li Y,Sun X,Liu Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:SIRT3 is an important regulator in cell metabolism, and recent studies have shown that it may be involved in the pharmacological effects of metformin. However, the molecular mechanisms underlying this process are unclear. METHODS:The effects of SIRT3 on the regulation of oxidative stress and insulin resista...

journal_title：Chinese medical journal

authors： Song Y,Shi J,Wu Y,Han C,Zou J,Shi Y,Liu Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and ...

journal_title：Chinese medical journal

authors： Luo D,Zhang Y,Bai Y,Liu X,Gong Y,Zhou B,Zhang L,Luo L,Zhou R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The controversy on the treatment strategy for severe acute pancreatitis (SAP) has never stopped for the past century. Even now surgical procedures play a decisive role in the treatment of SAP, especially in managing the related complications, but the rational indications, timing, and approaches of surgical i...

journal_title：Chinese medical journal

authors： Xu Y,Shao Q,Yang J,Yu X,Xu J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:First generation drug-eluting stents (DES) were associated with a high incidence of late stent thrombosis (ST), mainly due to delayed healing and re-endothelization by the durable polymer coating. This study sought to assess the safety and efficacy of the Nano polymer-free sirolimus-eluting stent (SES) in th...

journal_title：Chinese medical journal

authors： Zhang Y,Chen F,Muramatsu T,Xu B,Li Z,Ge J,He Q,Yang Z,Li S,Wang L,Wang H,He B,Li K,Qi G,Li T,Zeng H,Peng J,Jiang T,Zeng Q,Zhu J,Fu G,Bourantas CV,Serruys PW,Huo Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Accurate evaluation of coronary artery, aortic valve annulus diameter (AVAD), and cardiac function in patients with aortic valve disease is of great significance for surgical strategy. In this study, we explored the preoperative evaluation of low-dose sequence (MinDose sequence) scan of dual-source CT (DSCT)...

journal_title：Chinese medical journal

authors： Feng J,Wang XM,Ji XP,Li HO,Li Q,Guo WB,Wang ZJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Combination paclitaxel and carboplatin is currently a first-line regimen for ovarian cancer. However, many patients develop tumor recurrence or drug resistance to this regimen. The study aims to investigate the effectiveness and safety of an oxaliplatin + epirubicin + ifosfamide regimen for the treatment of ...

journal_title：Chinese medical journal

authors： Zhang G,Li XP,Liu BJ,Wang JL,Wang SJ,Cui H,Wei LH

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The change of glucose transporter 4 (GLUT4) expression could influence glucose uptake in the myocardial cells and then effect myocardial metabolism, which maybe one of the factor for the diabetes cardiovascular disease. This study aimed to explore the influence of glucose and insulin at different concentrati...

journal_title：Chinese medical journal

authors： Liu Q,Huang QX,Lou FC,Zhang L,Wang K,Yu S,Xu H,Wang Q,Zhang Y,Hou WK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is a growing public health problem with well-established risk factors. Other contributing factors, however, remain to be identified. Systemic inflammation in asthma plays a significant role in the development of other diseases. We therefore initiated a study to assess whether the...

journal_title：Chinese medical journal

authors： Liu DW,Zhen XG,Liang Y,Jing XG,Zhang TS,Zhang GJ,Liu ZS

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Clostridium difficile-associated diarrhea (CDAD) is a major public health problem because of significant morbidity and mortality, and many clinicians pay attention to Lactobacillus as a potentially effective treatment. The purpose of this meta-analysis was to evaluate the efficacy of Lactobacillus in the pre...

journal_title：Chinese medical journal

authors： Wu ZJ,DU X,Zheng J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Many recipients of implantable cardiac electronic devices have atrial fibrillation (AF) occurrences after device implantation, even if there is no previous history of AF, and some of the episodes are asymptomatic. The purpose of this study was to evaluate trends in AF burden following early AF detection in p...

journal_title：Chinese medical journal

authors： Chen KP,Dai Y,Hua W,Yang JF,Li K,Liang ZG,Shen FR,Chen SL,Su YG,Ding YS,Zhang S

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Dynesys dynamic stabilization system was first implanted in patients in 1994, and introduced to China in 2007. Therefore, it was a new technique for Chinese orthopedics and hence necessary to collect clinical data about Dynesys in China. The objective of this study was to report the preliminary results of Dy...

journal_title：Chinese medical journal

authors： Li HP,Li F,Guan K,Zhao GM,Shan JL,Sun TS

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is considered to have high value in the staging of mediastinal lymph nodes in lung cancer. The current study was conducted to investigate the diagnostic value of EBUS-TBNA in intrapulmonary lesions located near the central airway. ...

journal_title：Chinese medical journal

authors： Zhao H,Xie Z,Zhou ZL,Sui XZ,Wang J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:With aging, the human fracture risks gradually increase. This is mainly due to the corresponding changes of the biomechanical parameters of human bone presents with aging. We measured the microstructural parameters of lumbar bone from women in several age groups by micro-computed tomography and scanning elec...

journal_title：Chinese medical journal

authors： Jiang R,Liu GM,Bai HT,Wang TB,Wu H,Jia YY,Luo YG

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how ...

journal_title：Chinese medical journal

authors： Cao FJ,Zhang X,Liu T,Li XW,Malik M,Feng SQ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Serum expression of cytokines may provide information about the clinical outcome of advanced non-small cell lung cancer (NSCLC) patients. This study aimed to investigate the relationship between serum cytokine levels and the clinical outcome of erlotinib treatment in a second or third line setting in patient...

journal_title：Chinese medical journal

authors： Wang YS,Miao LY,Liu L,Cai HR,Ding JJ,Ren SX,Zhou CC,Schmid-Bindert G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease (GVHD), the commonest long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT), has a negative impact on patients' health related quality of life (HRQoL). This study was designed to investigate the HRQoL in patients with chronic GVHD in China. ...

journal_title：Chinese medical journal

authors： Mo XD,Xu LP,Liu DH,Chen YH,Zhang XH,Chen H,Han W,Wang Y,Wang FR,Wang JZ,Liu KY,Huang XJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. In this study, we collected a Han monilethrix family to detect the mutations in patients and investigated the correlation between the genotype and phenotype of monilethrix. METHODS:In this study, ...

journal_title：Chinese medical journal

authors： Ye ZZ,Nan X,Zhao HS,Chen XR,Song QH

更新日期：2013-08-01 00:00:00

abstract：:The RV lead position, either RVA or RVHS appears to make no difference in the response to CRT but the LV lead placement play a vital role.9,30 The latest activated regions of LV or areas without transmural myocardial scar for an optimal CRT are preferred. Currently, data demonstrate that no significant difference of c...

journal_title：Chinese medical journal

authors： Dong YX,Boodhna J,Yang YZ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Circumferential pulmonary vein isolation (CPVI), as the basal ablation strategy for treating atrial fibrillation (AF), not only isolates the connection between the left atrium (LA) and the pulmonary veins (PVs), but also induces extensive atrial endocardia damage. This could have an effect on the sinus pulse...

journal_title：Chinese medical journal

authors： Zhao L,Jiang WF,Zhou L,Liu X

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The human leukocyte antigen-G (HLA-G) has been considered to be an important tolerogeneic molecule playing an essential role in maternal-fetal tolerance, upregulated in the context of transplantation, malignancy, and inflammation, and has been correlated with various clinical outcomes. The aim of this study ...

journal_title：Chinese medical journal

authors： Xiao L,Zhou WQ,Shi BY,Feng K,He XY,Wei YX,Gao Y,Meng XY,Xiao W

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy. Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment. METHODS:In this study, the inhibitory effects of c-Met phosphorylation were obser...

journal_title：Chinese medical journal

authors： Gao SH,Liu C,Wei J,Feng Y

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Robotic assisted minimally invasive cardiac sugery is a new technique that uses small port sites and peripheral vessel cannulation for cardiopulmonary bypass (CPB) has been used. The right internal jugular vein (IJV) is commonly used for intraoperative venous access to the central circulation and identified ...

journal_title：Chinese medical journal

authors： Wang Y,Wang G,Gao CQ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous disease for which a strong genetic basis has been firmly established. Until now no studies have been undertaken to systemically explore the network of asthma-related genes using an internally developed literature-based discovery approach. This study was to explore asthma-related gen...

journal_title：Chinese medical journal

authors： Liang R,Wang L,Wang G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Whether an addition of OAC to double antiplatelet therapy for patients with an indication of chronic oral anticoagulation undergoing PCI-S may improve clinical outcomes is still debated. This meta-analysis aimed to update and re-compare the benefits and risks of triple antithrombotic therapy (TT) with double...

journal_title：Chinese medical journal

authors： Saheb KJ,Deng BQ,Hu QS,Xie SL,Geng DF,Nie RQ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Evidence has demonstrated that the distal lung, which includes airways of < 2 mm in diameter and lung parenchyma, constitutes an important component of asthma pathology. Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators and bronchoconstrictors involved in the asthmatic process. Guidelines ...

journal_title：Chinese medical journal

authors： Gao JM,Cai F,Peng M,Ma Y,Wang B

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension. This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension. METHODS:One hundred and eighty-...

journal_title：Chinese medical journal

authors： Chen T,Chen GH,Yang TS,Zhong ZY,An WS,Zhang XX,Li JD

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Double plate osteosynthesis is the standard treatment for intra-articular fractures of the distal humerus. However, there is still controversy concerning dual plate positions in terms of providing optimal stability. The purpose of this retrospective study was to compare the clinical outcomes in patients with...

journal_title：Chinese medical journal

authors： Lan X,Zhang LH,Tao S,Zhang Q,Liang XD,Yuan BT,Xu WP,Yin P,Tang PF

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The mortality of stroke patients is strongly affected by medical complications. However, there are limited data investigating the effect of in-hospital medical complications on the dependency of stroke patients worldwide. We prospectively and systematically investigated the effect of medical complications on...

journal_title：Chinese medical journal

authors： Wang PL,Zhao XQ,DU WL,Wang AX,Ji RJ,Yang ZH,Wang CX,Liu LP,Wang YL,Ju Y,Wang YJ,China National Stroke Registry (CNSR) investigators.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Precise evaluation of the live donor's liver is the most important factor for the donor's safety and the recipient's prognosis in living donor liver transplantation (LDLT). Our study assessed the clinical value of computer-assisted three-dimensional quantitative assessment and a surgical planning tool for do...

journal_title：Chinese medical journal

authors： Wei L,Zhu ZJ,Lü Y,Jiang WT,Gao W,Zeng ZG,Shen ZY

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease. DATA SOURCES:To identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15. STUDY SELECTION:Well-controlled, relat...

journal_title：Chinese medical journal

authors： Liu HT,Wang HC,Tao L,Li CX,Li F,Zhang YY,Liu BW

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The CYP2C19 G681A single polymorphism has been proven to affect clopidogrel responsiveness. However, the effect of coexisting polymorphisms of other genes has not yet been reported in the Chinese population. This study investigated the effect of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel re...

journal_title：Chinese medical journal

authors： Tang XF,Zhang JH,Wang J,Han YL,Xu B,Qiao SB,Wu YJ,Chen J,Wu Y,Chen JL,Gao RL,Yang YJ,Yuan JQ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Ahmed Glaucoma Valve implantation (AGVI) is used to treat refractory glaucoma. Breakdown of the blood-aqueous barrier (BAB) has been noted after some surgical techniques. The current study was designed to assess BAB disruption after AGVI. METHODS:Anterior chamber protein content was measured by the laser fl...

journal_title：Chinese medical journal

authors： Zhou MW,Wang W,Chen SD,Huang WB,Zhang XL

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Transcatheter aortic valve implantation (TAVI) has emerged as the treatment choice for non-operable patients with severe symptomatic aortic stenosis (AS) and may be a good alternative to surgery for those at very high or prohibitive surgical risk. We performed a meta-analysis to evaluate the comparative bene...

journal_title：Chinese medical journal

authors： Wu YC,Zhang JF,Shen WF,Zhao Q

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Alcohol has been used for treating simple renal cysts since 1981. Since then, various observational studies have examined the technique, but they differ significantly in the details of the procedures and efficacy measures used. This has made it difficult to assess the safety and efficacy of this technique. W...

journal_title：Chinese medical journal

authors： Li YZ,Li MX,Wang T,Yang LC,Feng P,Gou ZP,Yuan JY,Zhang W

更新日期：2013-03-01 00:00:00